JariwalaĬhapter 22 Vaccines Linked to Chemotherapy: A New Approach to Control Helminth Infections (pages 357–375): Sara Lustigman, James H. Bethony, Maria Victoria Periago and Amar R. Caffrey, Jurg Utzinger and Jennifer KeiserĬhapter 21 Barefoot thru' the Valley of Darkness: Preclinical Development of a Human Hookworm Vaccine (pages 341–356): Jeffrey M. ConderĬhapter 19 Praziquantel: Too Good to be Replaced? (pages 309–321): Livia Pica?Mattoccia and Donato CioliĬhapter 20 Drug Discovery for Trematodiases: Challenges and Progress (pages 323–339): Conor R. AroianĬhapter 17 Monepantel: From Discovery to Mode of Action (pages 283–296): Ronald Kaminsky and Lucien RufenerĬhapter 18 Discovery, Mode of Action, and Commercialization of Derquantel (pages 297–307): Debra J. SlatkoĬhapter 16 Promise of Bacillus thuringiensis Crystal Proteins as Anthelmintics (pages 267–281): Yan Hu and Raffi V. Taylor, Louise Ford, Achim Hoerauf, Ken Pfarr, Jeremy M. MartinĬhapter 15 Drugs and Targets to Perturb the Symbiosis of Wolbachia and Filarial Nematodes (pages 251–265): Mark J. Wolstenholme, Cedric Neveu, Jacques Cabaret, Claude L. de Hostos and Tue NguyenĬhapter 14 Antinematodal Drugs – Modes of Action and Resistance: And Worms Will Not Come to Thee (Shakespeare: Cymbeline: IV, ii) (pages 233–249): Alan P. RoyĬhapter 13 Anthelmintic Drugs: Tools and Shortcuts for the Long Road from Discovery to Product (pages 217–232): Eugenio L. HammerlandĬhapter 12 To Kill a Mocking Worm: Strategies to Improve Caenorhabditis elegans as a Model System for use in Anthelmintic Discovery (pages 201–216): Andrew R. Cozzie, Bakela Nare, Kerrie Powell, Ann E. SelzerĬhapter 10 Quantitative High?Content Screening?Based Drug Discovery against Helmintic Diseases (pages 159–179): Rahul SinghĬhapter 11 Use of Rodent Models in the Discovery of Novel Anthelmintics (pages 181–199): Rebecca Fankhauser, Linsey R. GearyĬhapter 9 Identification and Profiling of Nematicidal Compounds in Veterinary Parasitology (pages 135–157): Andreas Rohwer, Jurgen Lutz, Christophe Chassaing, Manfred Uphoff, Anja R. SkellyĬhapter 8 Mechanism?Based Screening Strategies for Anthelmintic Discovery (pages 121–134): Timothy G. GasserĬhapter 6 RNA Interference: A Potential Discovery Tool for Therapeutic Targets of Parasitic Nematodes (pages 89–103): Collette BrittonĬhapter 7 RNA Interference as a Tool for Drug Discovery in Parasitic Flatworms (pages 105–119): Akram A. GasserĬhapter 5 Harnessing Genomic Technologies to Explore the Molecular Biology of Liver Flukes?Major Implications for Fundamental and Applied Research (pages 73–87): Neil D. Roos and Fernan AgueroĬhapter 4 Recent Progress in Transcriptomics of Key Gastrointestinal Nematodes of Animals – Fundamental Research Toward New Intervention Strategies (pages 61–72): Cinzia Cantacessi, Bronwyn E. WalkerĬhapter 3 Integrating and Mining Helminth Genomes to Discover and Prioritize Novel Therapeutic Targets (pages 43–59): Dhanasekaran Shanmugam, Stuart A. With its well-balanced mix of high-profile contributors from academia and industry, this handbook and reference will appeal to a wide audience, including parasitologists, pharmaceutical industry, epidemiologists, and veterinary scientists.Content:Ĭhapter 1 Ligand?Gated Ion Channels as Targets for Anthelmintic Drugs: Past, Current, and Future Perspectives (pages 1–21): Kristin Lees, Ann Sluder, Niroda Shannan, Lance Hammerland and David SattelleĬhapter 2 How Relevant is Caenorhabditis elegans as a Model for the Analysis of Parasitic Nematode Biology? (pages 23–41): Lindy Holden?Dye and Robert J. The result is a broad overview of different drug target evaluation methods, including specific examples of successful drug development against helminthes, and with a whole section devoted to vaccine development. Code: B1650 System: Body (Covers functions that are generally inside of the passenger compartment) Category: Manufacturer (The code definition is assigned by manufacturers according to their vehicle basic system differences, implementation differences, or diagnostic strategy differences.This third volume in the successful 'Drug Discovery in Infectious Diseases' series is the first to deal with drug discovery in helminthic infections in human and animals.
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